Research
Our research interests involve utilizing transition metal complexes as Lewis acids to mediate novel and useful transformations. We have two independent research projects that utilize metals at the opposite end of the periodic table (titanium and gold). While working in the lab, undergraduate students will learn to appreciate the difference between these two Lewis acids (hard and soft) and how they can mediate organic transformations.
Gold(I) Catalyzed Cyclization Reactions
Gold complexes are unique among transition metals because they typically act as π-Lewis acids activating alkynes toward nucleophilic addition without the propensity toward redox processes. While much has been reported on gold-catalyzed intramolecular cyclizations, most of these transformations occur through a 5-exo-dig process affording five-membered rings. We are exploring the reactions of ortho-substituted phenylacetylenes that are proposed to proceed, instead, through a 6-endo-dig pathway.
Titanium-Mediated Reactions
We are developing a direct and selective two-step sequence for the construction of cyclobutanone rings from aldehydes. The key step in this sequence utilizes low-valent titanium intermediates (Kulinkovich reagents) as 1,2-dinucleophilic compounds.
Student Mentorship
As a faculty member at a primarily undergraduate, liberal arts institution, the foremost motivation for my research is inspiring students. My mentoring style relies on a progression of responsibilities. As students begin research, my role in the lab is hands-on, working side-by-side with my students to teach them laboratory skills and techniques as well as guide them through the scientific method. As they progress through the program, undergraduate researchers become more independent, developing their own hypotheses and finding creative ways to test their own research questions. I have been fortunate to mentor students who come from a wide variety of cultural and socioeconomic backgrounds. A diversity of perspectives provides opportunities to expand our research in new directions; this would not be possible if I was working alone. I understand that I have as much to learn from my students as they have to learn from me.